hapten


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Related to hapten: complete antigen, Tolerogen

hap·ten

 (hăp′tĕn′) also hap·tene (-tēn′)
n.
A small molecule that reacts with a specific antibody but does not induce an immune response unless bound to a larger molecule, usually a protein.

[German : Greek haptein, to fasten + German -en, noun suffix (from Greek -ēnē, -ene).]

hap·ten′ic adj.

hapten

(ˈhæptən) or

haptene

n
(Physiology) immunol an incomplete antigen that can stimulate antibody production only when it is chemically combined with a particular protein
[C20: from German, from Greek haptein to fasten]

hap•ten

(ˈhæp tɛn)

also hap•tene

(-tin)

n.
a substance that reacts with antibodies but cannot by itself stimulate more antibodies; a partial antigen.
[1920–25; < German < Greek hápt(ein) to grasp + German -en -ene]
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References in periodicals archive ?
In doing so, UV energy causes binding of the drug as a hapten to proteins in epidermal cells, creating an antigen which synthesizes lymphocytes in the vicinity; all this occurs in the predisposed and previously sensitized person (type IV reaction) (9,14).
9) Alternatively it may act as a hapten, initiating an immune reaction that results in immune-mediated destruction of the neutrophil.
DA is a characteristic hapten with a low molar mass of 311 g/mol, and it cannot induce immune response in animal.
The impact of pre-analytical processing on staining quality for H&E, dual hapten, dual color in situ hybridization and fluorescent in situ hybridization assays.
6] The offending drug acts as hapten and interacts with HLA alleles to activate the T-lymphocytes.
In the first phase, the complex which is formed from the reaction between hapten and protein get recognized by Langerhans cells, which subsequently migrate to lymph nodes, where [CD4.
Companies Mentioned in this Report: Hapten Sciences, Inc.
The vaccine "cocktail," as Janda calls it, has three components: a large protein that carries the druglike molecules into the body; a molecule called a hapten, chemically designed to induce an immune response to heroin and its metabolites 6-AM and morphine; and finally, alum, an agent commonly added to vaccines to stimulate release of cytokines, proteins that help rally the immune cells to fight invaders.
OligoADP-ribosylated histone was considered as if hapten-carrier system as mentioned above, that is, the carrier protein should be histone, and oligo(ADP-ribose) be equivalent to hapten in this system.
This process is named haptenization and the sensitizing chemistry is termed hapten.