hematin


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Related to hematin: haematin, porphyria

he·ma·tin

 (hē′mə-tĭn)
n.
A blue to blackish-brown compound, C34H32N4O4·FeOH, formed in the decomposition of hemoglobin.

heme

(him)

n.
an unstable, deep red, iron-containing blood pigment, C34H32N4O4Fe, obtained from hemoglobin.
[1920–25; shortening of hemoglobin]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.hematin - a complex red organic pigment containing iron and other atoms to which oxygen binds
pigment - dry coloring material (especially a powder to be mixed with a liquid to produce paint, etc.)
haemoglobin, Hb, hemoglobin - a hemoprotein composed of globin and heme that gives red blood cells their characteristic color; function primarily to transport oxygen from the lungs to the body tissues; "fish have simpler hemoglobin than mammals"
myoglobin - a hemoprotein that receives oxygen from hemoglobin and stores it in the tissues until needed
cytochrome - (biochemistry) a class of hemoprotein whose principal biological function is electron transfer (especially in cellular respiration)
References in periodicals archive ?
2% of women with uterine fibroids achieving clinical response compared to placebo, as measured by the alkaline hematin method.
Patients were included if they were premenopausal, aged 18-50 years old, had prolonged bleeding in at least 4 of the last 6 menstrual periods, had menstrual blood loss of at least 80 mL by cycle by the alkaline hematin method, and had at least one discrete leiomyoma without a uterine size greater than 20 weeks.
Tappel, The Mechanism of the Oxidation of Unsaturated Fatty Acids Catalyzed by Hematin Compounds, Arch.
The time period until the high porphobilinogen levels suggested that the attack began to decline and thus hematin could not be easily obtained.
As per blood bank protocol, hemoglobin of all prospective blood donors which include replacement donors (relatives and friends), family replacement donors (family members) and voluntary donors was initially screened by copper sulfate solution specific gravity method followed by alkaline hematin method for recording hemoglobin level.
Other studies have reported promising correlations between measured blood loss and laboratory methods that quantify the blood loss using absorbent paper or sanitary pads and photometric measurement of alkaline hematin (18).
17) Tissues and blood turn brown-grey after fixation by the cross-linking effect of formalin and conversion of Hb into other compounds, including blue-brown hematin (Figure 3, B).
The primary efficacy outcome of the study is a clinically-meaningful reduction in menstrual blood loss based upon the alkaline hematin method, a standardized centrally-assessed quantitative measurement of menstrual blood loss.
In the alkaline hematin detergent (AHD575) method, red blood cells are lysed with Triton X-l 00 and sodium hydroxide (NaOH) at pH 13, which converts hemoglobin to hematin, forming a stable complex with Triton X-100.
Specific treatment with hematin should be started immediately, with later analysis of plasma and, if required, fecal porphyrins to identify the specific type of acute porphyria.
The double-blind, placebo-controlled clinical trial tested premenopausal women between 18 and 50 years old with cyclic (22 to 35 days) abnormal uterine bleeding in >=4 of the last 6 menstrual cycles, menstrual blood loss >=80 mL as measured by the alkaline hematin method over the first 8 days of menses, >=1 discrete uterine fibroid of any size and location observable by transvaginal ultrasound, follicle-stimulating hormone <=20 mIU/mL, and uterine volume <=20 weeks by exam.
Acute intermittent porphyria with peripheral neuropathy: A follow-up study after hematin treatment.