Summary: Clonal hematopoiesis
of indeterminate potential, or CHIP, is emerging as a major cause of heart attacks and stroke, as deadly as high blood pressure or cholesterol
They lost their ability to promote hematopoiesis
or become other types of cells, like fat.
Several patients with ineffective hematopoiesis
and cytopenia, such as aplastic anemia (1), myelodysplastic syndromes (MDS) (2,3), myelofibrosis (4-6), and b-thalassemia (7,8), require multiple erythrocyte transfusions leading to iron overload (9,10).
He plans to generate a mouse model for the combined RUNX1 and STAG2 mutations and study hematopoiesis
and leukemia progression.
The findings show that the classical model of a hierarchical developmental tree that starts from multipotent stem cells holds true for hematopoiesis
Pereira's laboratory is focused on the study of the mechanisms of hematopoiesis
, the fundamental and complex process that generates many different cell types including all immune cells, and its role in conferring immunity.
The earlier return of total and differential leukocyte towards normal in ghrelin treated myelosuppressed rats as compared to chemotherapeutic and chemotherapeutic, ghrelin and GHRH antagonist group suggest valuable role of ghrelin in stimulating hematopoiesis
Molecular and genetic studies carried out in the past 2 decades have shown different regulatory processes of hematopoiesis
I previously identified the fetal specific RNA binding protein Lin28b as a post-transcriptional molecular switch capable of inducing fetal-like hematopoiesis
in adult bone marrow HSPCs (Yuan et al.
The company added that myelodysplastic syndromes are a complex and heterogeneous group of bone marrow failure disorders characterised by ineffective hematopoiesis
and poor prognosis.
The analytical units (XN-10) provide a comprehensive CBC and differential along with advanced measures of hematopoiesis
through advanced, reportable parameters: automated IG, NRBC (with every CBC), reticulocyte hemoglobin RET-He and immature reticulocyte fraction (IRF), immature platelet fraction (IPF) and fluorescent platelet count (PLT-F) and automated body fluid count (with a 2-part differential).
Other topics include the transcriptional control of dendritic cell development, the genomics of immune diseases and new therapies, chemokines and chemokine receptors in lymphoid tissue dynamics, the innate lymphoid cell precursor, retinoic acid and retinoic acid receptors as pleiotropic modulators of the immune system, auto-antigens as partners in the initiation and propagation of autoimmune rheumatic diseases, fate mapping and quantitation of hematopoiesis
in vivo, coinhibitory pathways in immunotherapy for cancer, and broadly neutralized antibodies to HIV and their role in vaccine design.