References in periodicals archive ?
These experiments demonstrated that XLR-11 undergoes phase I and II metabolism, producing more than 25 metabolites (including 7 major metabolites) resulting from hydroxylation, carboxylation, hemiketal and hemiacetal formation, etc.
XLR-11 was metabolized by phase I and II enzymes in human hepatocytes; more than 25 XLR-11 metabolites were produced by hydroxylation, carboxylation, hemiketal and hemiacetal formation, internal dehydration, and further glucuronidation of some oxidative metabolites.
The students expect to see a mass spectrum of the aldehyde but actually observe formation of the acetal or hemiacetal and are asked to provide a mechanism to explain their results.