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hemoprotein |
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We hypothesized that after PM exposure, events linked to inflammation, such as hemoprotein deposition and oxidative stress, should be present at the microvascular level. Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein oxygenase-3. The antioxidant properties of Ergothioneine appear to be related to at least four molecular activities: the ability to scavenge free radicals; to chelate, or combine with, various divalent metallic cations (positively charged ions); to activate antioxidant enzymes such as glutathione peroxidase (Se-GPx) and MnSOD and to inhibit superoxide-generating enzymes such as NADPH-Cytochrome c reductase; and to affect the oxidation of various hemoproteins such as hemoglobin and myoglobin. |
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