heparan sulfate

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Related to heparan sulfate: keratan sulfate, dermatan sulfate

hep·a·ran sulfate

A glycosaminoglycan found on cell surfaces and basement membranes in mammals that regulates a wide variety of biological processes, including angiogenesis and blood coagulation. Also called heparitin sulfate.

[hepar(in) (to which it is close in structure) + -an.]
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Our study showed that all GAG components other than heparan sulfate were affected in the early stages of essential hypertension.
MPS 7 is an extremely rare autosomal recessive lysosomal storage disorder characterized by a deficiency of the lysosomal enzyme Beta-glucuronidase, required for the degradation of the glycosaminoglycans dermatan sulfate (DS) and heparan sulfate (HS).
The authors show that HIV relies on heparan sulfate to attach to sperm, but not mannose receptors as previously predicted.
Heparan sulfate plays a central role in a dynamic in vitro model of protein-losing enteropathy.
MPS IIIB is resulted by insufficiency in the enzyme alpha-N-acetyglucosaminidase (NAGLU), one of the four enzymes needed for heparan sulfate (HS) degradation.
Cell surface heparan sulfate and its roles in assisting viral infections.
Localization of a functional site on Herpes simplex virus type 1 glycoprotein C involved in binding to cell surface heparan sulfate.
Importantly, the authors found increased amounts of serum proteins, increased differential protein excretion, and increased amounts of heparan sulfate in the urine of DHF patients.
VEGF in mouse has three isoforms, VEGF 120, 164, and 188, that differ in their ability to bind heparan sulfate proteoglycans on the cell surface and in the extracellular matrix (ECM) (4, 5).
Even more incriminating is evidence that when heparanase degrades heparan sulfate, the reaction releases growth factors.
This results in an inability of lysosomes to effect the stepwise degradation of certain glycosaminoglycans (GAGs), namely dermatan sulfate and heparan sulfate, a process essential for normal growth and maintenance of tissues.