22) Similar to the syndrome in children, the peregrine falcon also showed a heterophilic
leukocytosis, but despite severe neurologic deficits in the hind limbs, further signs of inflammation were not observed.
Throughout the dermis, small perivascular to interstitial heterophilic
and pleocellular infiltrates were present.
Given the success in overcoming TgAB interferences, we believed that this methodology would overcome interferences due to heterophilic
antibodies (HAB), which may result in false-high Tg measurements in immunometric assays.
There are a number of other factors, which reduce the utility of serum Tg measurements even in the current medical environment of total thyroid gland removal for thyroid cancer, namely antibody interferences, chiefly due to anti-Tg autoantibodies (TgAB) and, to a lesser extent, heterophilic
Human anti-species and heterophilic
antibody interference against reagent antibodies has been well documented, and other interfering antibodies have also been reported, (1-3) Misdiagnosis, subsequent inappropriate treatment, and adverse consequences for the patient can result from interferences yielding false results.
The presence of heterophilic
antibodies in high titers may lead to analytical errors in two-site immunoassays (2).
Expression of CD6, a heterophilic
receptor for ALCAM expressed mainly in lymphocytes, has not been determined in the uterine endometrium or conceptuses in pigs so far, but it is possible that ALCAM may recruit and activate endometrial lymphocytes.
Humans with recent exposure to mononucleosis are more prone to develop antibodies against animal antibodies, and those with IgA-deficiency syndrome often have false-positive assay problems due to heterophilic
This new automated TIA version addresses the heterophilic
interference found in the previous version.
growth under aerobic and anoxic conditions", Water Res.
The 13 chapters on therapeutic drug monitoring discuss such issues as monitoring free drug concentration; analytical techniques for measuring concentrations of therapeutic drugs in biological fluids; the pre-analytical phase of drug testing; the effect of hemolysis, high bilirubin, lipemia, paraproteins, and system factors on therapeutic drug monitoring; interferences with measurement of anticonvulsants; pitfalls in measuring antidepressant drugs; immunosuppressive drugs; therapeutic monitoring in HIV/AIDS; pharmacogenomics and personalized medicine; interference of heterophilic
and other antibodies in measurement of therapeutic drugs by immunoassays; and drug-herb and drug-food interactions and their impact on drug monitoring.
The ED18 B-cells express pro-apoptotic proteins, cell adhesion molecules with both homo- and heterophilic
binding activity and various immune response receptors.