6,12) The congenital type is seen in rare syndromes, including congenital plaque-like osteomatosis, Albright hereditary osteodystrophy, fibrodysplasia ossificans progressiva, and osseous heteroplasia
Given these physical, chemical, and mechanical traumas, the cell structures affected by the inhaled, nasal, and oral sprayed insulin can undergo changes such as metaplasia, in which cells change from their original mature, differentiated type into another cell type; dysplasia, in which the cell change (different form) is indicative of an early step towards transformation into a tumor (cancer; for example, leukoplakia of the oral cavity); or heteroplasia
, the abnormal cell growth of existing cells as seen in blood vessels of hypertensives and in bronchiolar asthmatics.
4) Finally, many systemic diseases can lead to auricular ossification, including congenital plaque-like osteomatosis, Albright hereditary osteodystrophy, fibrodysplasia ossificans progressiva, Addison disease, osseous heteroplasia
, and collagen vascular diseases, especially CREST syndrome and childhood dermatomyositis.