In preclinical animal testing, AST-OPC1 administration led to remyelination of axons, improved hindlimb
and forelimb locomotor function, dramatic reductions in injury-related cavitation and significant preservation of myelinated axons traversing the injury site.
Dystrophin involved in the susceptibility of slow muscles to hindlimb
unloading via concomitant activation of TGF-betal/Smad3 signaling and ubiquitin-proteasome degradation in mice.
Ldi will allow us to confirm cessation of blood flow to the hindlimb
during hli surgery and will allow measurement of blood flow recovery after stem cell treatment.
Notably, the hindlimb
muscles are generally used to isolate the skeletal muscle satellite.
Furthermore, small improvements to experimental methodology, such as a reduction in injection volume (thereby avoiding possible hindlimb
damage), resulted in a previously reported adverse neurobehavioral effect (Hornig et al.
2010) also pointed out that the hindlimb
mechanics of vertical climbing and quadrupedal knuckle-walking are rather similar, involving highly flexed postures of the hip and knee, and suggested that it is in fact these locomotor behaviours that are likely to be functionally and ecologically linked.
Lateralized agonistic responses and hindlimb
use in toads.
Use of combination of low-dose cyclosporine and RS-61443 in a rat hindlimb
model of composite tissue allotransplantation.
04%, LNa) and, therefore, in a prehypertensive state, Gordon and Mark (10,13) demonstrated a partial arterial baroreceptor impairment (vs Dahl SR rats on a LNa diet) that translated into a diminution of both the heart rate (HR) and the neurosympathetic-mediated hindlimb
vascular resistance baroreflex sensitivities, without altering the baseline MAP.
cell-derived microvesicles improve neovascularization in a murine model of hindlimb
To demonstrate clinical potential of ciPSCs to treat models of injury, we generated endothelial cells (ciPSC-ECs) and used these cells to treat immunodeficient murine models of myocardial infarction and hindlimb
Cattle infected with BSE generally show gait abnormalities, particularly of the hindlimb
(ataxia), along with aggressive behavior, apprehension, tremors and hyperreactivity to stimuli.