hyperalgesic


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hyperalgesic

(ˌhaɪpərælˈdʒiːzɪk)
adj
(Medicine) med characterized by an extreme sensitivity to pain
References in periodicals archive ?
22, 2012 /PRNewswire/ -- A novel patented technology (Algotect) has been developed to accurately identify patients who are cold hyperalgesic and require specific pain management.
In a case series, the alpha 2-adrenergic agonist clonidine was delivered topically to the patients with hyperalgesic skin due sympathetically maintained pain.
They found that the compounds significantly reduced pain-related activities in isolated microglia, and that these compounds also significantly reversed hyperalgesic behaviour in the experimental rats.
Significant reduction in paw withdrawal and cold allodynia thresholds confirms nocifensive behavioural and hyperalgesic effect.
On-cells are inhibited by [micro]-opioids, which, along with other correlations observed between firing rate and various hyperalgesic phenomena, suggests that they are pronociceptive [15-17].
Unfortunately, there is no definitive physical pathology regarding FM; however, evidence suggests a number of physiological mechanisms including dysregulated pain modulation within the central nervous system, alteration of brainwave patterns affecting sleep, and a hyperalgesic response to nociception (Kosek, Ekholm & Hannson, 1996; Okifuji, Turk, & Marcus, 1999).
In studies using experimental pain induction, subjects on MMT are hyperalgesic and have a much lower tolerance to the cold pressor test compared with control groups (47-49).