Additionally, within the field of Endocrinology, Cook Children's team of specialists cured a baby afflicted with hyperinsulinism
using 18F DOPA, a new drug used to diagnose focal lesions in children with the rare disease.
He also found out that hypoglycaemia was seen in infants with Rh-D haemolytic disease due to islet cell hyperplasia and hyperinsulinism
, secondary to release of metabolic byproducts such as glutathione from lysed red cells.
Researchers from the University of Geneva (UNIGE), Switzerland, supported by the Swiss National Science Foundation (SNSF) succeeded in precisely describing the effects of a frequent genetic mutation in cases of congenital hyperinsulinism
UCP2 is a member of the mitochondrial carrier family whose loss of function mutation can cause hyperinsulinism
, whereas its overexpression is associated with the efflux of TCA cycle intermediates out of the mitochondria, thereby reducing acetyl-CoA-oxidizing substrates in the mitochondria (Gonzalez-Barroso et al.
In my patients with cancer, I find some degree of hyperinsulinism
in nearly all patients, usually beginning within months of the onslaught of fears and doubts, real or imagined, concerning cancer diagnosis as well as the toxicity and efficacy of treatment options.
5 IL-6 itself causes rise in serum insulin levels by augmenting release of Glucagon-like peptide (GLP) from intestinal cells as well as pancreatic alpha cells aggravating the hyperinsulinism
Yudkin J, Szanto SS: Hyperinsulinism
resulting in pancreatic [beta]-cell hyperplasia and hyperinsulinism
Kitabchi, "Correlation of hyperandrogenism with hyperinsulinism
in polycystic ovarian disease," Journal of Clinical Endocrinology and Metabolism, vol.
The little boy, identified as Mohammad, of Afghan nationality, was born with congenital hyperinsulinism
[excessive production of insulin by the pancreas].
Codes used pertained to: metabolic syndrome, obesity unspecified, morbid obesity, overweight, abnormal weight gain, hypertension unspecified, elevated blood pressure without the diagnosis of hypertension, acquired acanthosis nigricans, hyperinsulinism
, impaired fasting glucose, impaired glucose tolerance test, pure hypercholesterolemia, pure hypertriglyceridemia, mixed hyperlipidemia and other unspecified hyperlipidemia.
McCormack of the diabetes center for children and the congenital hyperinsulinism
center at Children's Hospital of Philadelphia.