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hyperinsulinism |
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| Persistent hyperinsulinism in infants or children is a complex disorder that requires prompt evaluation and treatment by a specialist. Approximately 50% of insulin is normally cleared in its first pass through the liver; therefore, peripheral delivery causes significant peripheral hyperinsulinism and reduces the exposure of the liver to high insulin concentrations. Other causes of postprandial hypoglycemia can include overactive islet cells, sometimes caused by excess numbers of cells, a tumor in the pancreas that produces too much insulin, or familial hyperinsulinism (hereditary production of too much insulin), which in severe cases can necessitate removal of the pancreas. |
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