hypodiploidy

hypodiploidy

(ˌhaɪpəʊˈdɪplɔɪdɪ)
n
(Medicine) med a deficiency of chromosomes less than the diploid number
References in periodicals archive ?
Out of 1001 cases, 37 per cent were found positive for various abnormalities like; Del13q(RB1), Del17p(TP53), t (4;14), t(11;14), t(14;16), 1q, Hypodiploidy and Hyperdipolidy etc.
Whereas, Kim et al found that the prognostic factors for reduced overall survival rate in patients with IgD multiple myeloma were advanced age, the presence of cytogenetic abnormalities such as del(13) or hypodiploidy, extramedullary plasmacytoma, and high serum p2 microglobulin.
In ALL, cytogenetic abnormalities can have an effect on prognosis and response to treatment as hyperdioploidy has a better outcome than hypodiploidy.
15] Whole-chromosome aneuploidy, including hyperdiploidy and hypodiploidy is the somatic mutation that can predispose to tumor development.
5 g/dL Serum calcium >3 mmol/L High concentrations of M-protein (IgG>70 g/L, IgA>50 g/L or Bence-Jones protein >12g/24 hours) Other Cytogenetic (by conventional prognostic karyotyping and by FISH): markers: Good/Average: Hyperdiploidy, t(11;14) Bad/poor: Hypodiploidy, Deletion 13q on conventional cytoegentics, t(4;14), t(14;16), chromosome 1 abnormalities, 17p deletion Others: Advanced age, poor performance status, high LDH, high CRP, low platelets, M-protein (e.
Hypodiploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia.
For example, SNP allelic patterns can help to distinguish true high hyperdiplody from duplication of hypodiploidy, providing insight into the disease evolution.
9% of children and 4% of adults showed hypodiploidy with 40-45 chromosomes.
Adult B lymphoblastic leukaemia/lymphoma with hypodiploidy (--9) and a novel chromosomal translocation t(7;12)(q22;p13) presenting with severe eosinophilia--case report and review of literature.
Cytogenetic abnormalities were classified into 2 groups, as follows: 1) high risk: t(11q23)/MLL, t(9;22)/bcr-abl, hypodiploidy (<45 chromosomes), 1(1;19), t(8q24)/C-MYC, and complex karyotype; 2) standard risk: normal karyotype, hyperdiploidy, and other structural aberrations.