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hypoglycaemic agent |
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Individuals with Type A insulin resistance who develop frank diabetes require large doses (>200 units/day) of subcutaneous insulin, oral hypoglycaemic agents and insulin sensitizers and despite this intense regimen glycemic control remains poor and these patients are at high risk of the complications of diabetes, such as cardiovascular disease, nephropathy, retinopathy and neuropathy. Even after administration of hypoglycaemic agents such as tolbutamide, little change in blood glucose levels is seen (2). |
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