Findings demonstrated increased all-cause mortality in the hypogonadal
men who were not treated compared to those who received TRT; no statistically significant difference in the prevalence of MI, TIA/CVA or PE was found between the groups.
7,8) Coupled with the fact that prior anabolic steroid use is common in young men seeking treatment for symptomatic hypogonadism, (9) the potential for decreased spermatogenic capacity and compromised reproductive function in young, hypogonadal
men is possible.
The study investigators examined three parallel, prospective, ongoing, cumulative registry studies of over 1,000 men and their analysis showed that longterm testosterone therapy in hypogonadal
men was safe and did not increase the risk of prostate cancer.
Citing separately published data finding that "serum testosterone levels were proved to be an independent negative predictor for developing arterial stiffness, assessed from the peak systolic and end diastolic diameters of the common carotid artery and simultaneous brachial artery blood pressure," Kelly and Jones submit: "Testosterone has demonstrated anti-inflammatory effects clinically and [testosterone replacement therapy] can improve atherosclerosis assessed non-invasively in hypogonadal
men and in animal studies.
Some studies show short-term benefits in selected groups of hypogonadal
men, but long-term safety studies are lacking.
Approval was based on the results of a phase III, 84-week, single-arm study of 130 hypogonadal
men (mean age, 54 years), which determined that TU was an effective testosterone replacement therapy, based on serum testosterone levels.
Washington, Oct 24 ( ANI ): A new study has suggested that testosterone treatment in hypogonadal
(testosterone deficient) men restores normal lipid profiles and may reduce the risk of cardiovascular disease.
In view of the emerging evidence suggesting that androgen deficiency is a risk factor for CVD, androgen replacement therapy could potentially reduce CVD risk in hypogonadal
8) evaluated prostatic changes in hypogonadal
men with and without high-grade intraepithelial neoplasia (PIN), which is considered to be a prostatic precancerous lesion after one year of TRT.
2005;20:1548-61) and that testosterone replacement may improve trabecular architecture in hypogonadal
women, children, and hypogonadal
men) and should be avoided" (6, 7).
The majority of elderly men with dysthymic disorder had total testosterone concentrations in the hypogonadal