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 (hī′pō-gō′năd-ĭz′əm, -gŏn′ə-dĭz′əm)
Inadequate functioning of the testes or ovaries as manifested by deficiencies in gametogenesis or the secretion of gonadal hormones.


(ˌhaɪ pəˈgoʊ næˌdɪz əm, -ˈgɒn æ-)

n. Pathol.
1. diminished hormonal or reproductive functioning in the testes or the ovaries.
2. a manifestation of this, as delayed pubescence.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.hypogonadism - incompetence of the gonads (especially in the male with low testosterone); results in deficient development of secondary sex characteristics and (in prepubertal males) a body with long legs and a short trunk
eunuchoidism, male hypogonadism - the state of being a eunuch (either because of lacking testicles or because they failed to develop)
Kallman's syndrome - hypogonadism with anosmia; a congenital sexual disorder that prevents the testicles from maturing at puberty
incompetence - inability of a part or organ to function properly
References in periodicals archive ?
Possible causes of amenorrhea include pregnancy, polycystic ovary syndrome, thyroid abnormalities, hyperprolactinemia, primary ovarian insufficiency, or hypogonadal amenorrhea, typically stimulated by the first instance of anorexia, Crohn's disease, celiac disease, or a gluten intolerance.
Low testosterone is usually defined as a testosterone level below 300 ng/dL However, the authors concluded in their cohort that up to 20% of patients who had a testosterone level of greater than 300 ng/dL were actually hypogonadal if bioavailable testosterone (BT) was calculated using sex hormone-binding globulin (SHBG).
Hypogonadal symptoms in young men are associated with a serum total testosterone threshold of 400 ng/dl.
There Is no evidence that putting a hypogonadal man on testosterone increases his risk of getting prostate cancer," says Eric Klein, MD, chairman of Cleveland Clinic's Glickman Urological & Kidney Institute.
According to the company, LPCN 1021 is a novel twice-a-day oral Testosterone Replacement Therapy product candidate containing Testosterone Undecanoate that is designed to help restore normal testosterone levels in hypogonadal men.
A moderated poster presentation featuring additional data from the same 52 week phase 3 study which tracked psychosexual function in hypogonadal men will also be presented at the same meeting on November 3, 2016.
Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (kallmann) syndrome.
4) For years thereafter, based on the results of this small sample, it was globally accepted that any history of PCa was an absolute contraindication for TRT in hypogonadal men.
There is no clinical advantage to using mass spectroscopy for measuring total testosterone, although the results may be more precise and accurate at very low levels that are not normally seen even in hypogonadal men.
Our results are in agreement with a large body of literature from the last 20 years supporting testosterone supplementation of hypogonadal men as a valuable strategy in improving a patient's metabolic profile, reducing body fat, and increasing lean muscle mass, which would ultimately reduce the risk of heart disease "There is a definite need for large multicenter, randomized trials to determine the true risk," Dr.
Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men--a clinical research center study.
The study investigators examined three parallel, prospective, ongoing, cumulative registry studies of over 1,000 men and their analysis showed that longterm testosterone therapy in hypogonadal men was safe and did not increase the risk of prostate cancer.