The FDA warns that the long-term use of PPIs is associated with decreased calcium absorption, leading to bone fractures, decreased absorption of magnesium leading to hypomagnesaemia
and heart arrhythmias, increased incidence of pneumonia, and increased incidence of Clostridium difficile infections.
in long-term users of proton-pump inhibitors.
Other effects include tubular dysfunction (membrane permeability), hypokalaemia, renal tubular acidosis (bicarbonate wasting type 1/distal), diabetes insipidus, and hypomagnesaemia
4 sec Long Myocarditis, Hypocalcaemia, Hypomagnesaemia
, Hypokalemia, Hypothyroidism, Stroke.
in serum can occur when total body content is normal or low.
Loop diuretics, as furosemide, induce several effects such as metabolic alkalosis, ototoxicity, hyperuricemia, hypomagnesaemia
, allergic reactions, each others (Jackson et al.
Major adverse effects of amphotericin B deoxycholate include renal impairment due to renal tubular toxicity (usually in the second week of therapy), hypokalaemia, hypomagnesaemia
, anaemia, febrile reactions and chemical phlebitis.
Other diseases, such as hemochromatosis and hypomagnesaemia
, have an associated component with CPPD deposition.
Because of pivotal role of magnesium in electrolyte homeostasis, hypomagnesaemia
is the common finding among the hospitalized patients and in general population.
Clinical aspects of hypomagnesaemia
in hospitalized patients and in susceptible individuals are discussed.
, a consequence of some platinum-containing chemotherapeutic agents and eclampsia, has also been implicated in increasing blood-brain barrier permeability.
is also reported to be a cause of extended QT intervals (23).