Twelve of the 15 patients died within 30 days of the last dose of Portrazza and had comorbid conditions including history of coronary artery disease (n=3), hypomagnesemia
(n=4), chronic obstructive pulmonary disease (n=7), and hypertension (n=5).
Of side effects associated with PPIs, significantly more PCPs than gastroenterologists expressed concern about hypomagnesemia
is a relatively common side effect for both Cetuximab and Panitumumab (Saif, 2008); their product monographs cite incidences of 43% and 39%, respectively (Cancer Care Ontario, 2014b, 2014c).
and inflammation: clinical and basic aspects.
The most serious adverse reactions of Vectibix are pulmonary fibrosis, pulmonary embolism, severe dermatologic toxicity complicated by infectious sequelae and septic death, infusion reactions, abdominal pain, hypomagnesemia
, nausea, vomiting and constipation.
Citalopram is not recommended for patients with congenital long QT syndrome, bradycardia, hypokalemia, or hypomagnesemia
, recent acute myocardial infarction, or uncompensated heart failure.
15,17) Notably, the secondary hypocalcemia cannot be corrected via calcium supplementation alone; the hypomagnesemia
must be rectified before the calcium levels normalize.
Hemodilution, hormonal changes, stress-related epinephrine release, diabetes mellitus, postoperative use of digoxin, [beta]-blockers and diuretics are thought to be contributing factors for the development of postoperative hypomagnesemia
Most patients with drug-induced TdP have one or more risk factors such as advanced age (>65 years), bradycardia, hypokalemia, hypomagnesemia
, occult or latent congenital LQTS, and female gender (7).
Monitor patients periodically for hypomagnesemia
, hypocalcemia and
Adverse events reported in >30% of renal, cardiac or liver transplant patients receiving CellCept (in combination with cyclosporine and corticosteroids) were pain, fever, headache, asthenia, anemia, leucopenia (patients should be monitored for neutropenia; dosing should be interrupted or the dose reduced if neutropenia develops), thrombocytopenia, leukocytosis, urinary tract infection, hypertension, hypotension, peripheral edema, hypercholesteremia, hypokalemia, hyperglycemia, creatinine, BUN and cough increased, hypomagnesemia
, diarrhea, constipation, nausea, vomiting, respiratory infection, dyspnea, lung disorder, pleural effusion, tremor and insomnia.
The profound hypocalcemia was unlikely to be due to causes such as the mild degree of hypomagnesemia
and the lack of PTH response to magnesium repletion (ie, hypomagnesemia
can cause acute increase in PTH or impair PTH secretion if prolonged).