Ltd,, Kyowa Kirin International PLC and Ultragenyx Pharmaceutical announce that Crysvita has received a positive European Commission decision granting a conditional marketing authorisation to Kyowa Kirin for the treatment of X-linked hypophosphatemia
with radiographic evidence of bone disease in children 1 year of age and older and adolescents with growing skeletons.
The most frequent all causality Grade 3-4 adverse reactions (>=5%) in patients treated with Cabometyx were hypertension, diarrhea, hyponatremia, hypophosphatemia
, palmar-plantar erythrodysesthesia, fatigue, increased ALT, decreased appetite, stomatitis, pain, hypotension, and syncope.
Patients with hypophosphatemia
, hyperparathyroidism, postmenopausal women and male patients older than 50, as indicated in the current HIV infection management guidelines were recruited for the study.
Other clinically relevant abnormalities were a moderate, proportional hyponatremia and hypochloridemia, moderate to marked hypocalcemia and hypophosphatemia
, mild hyperuricemia, and hyperglycemia.
Biochemical tests may reveal hypokalemia, metabolic acidosis, hypophosphatemia
, hypocalcemia, low carnitine level, and hyponatremia.
The main complications of RM are acute kidney failure, electrolyte imbalance, especially hyperkalemia which leads to arrhythmia, hypophosphatemia
1,7) A study found that cutaneous skeletal hypophosphatemia
syndrome, manifested as NS and vitamin D-resistant rickets, has identical ras mutations in both skin and bone tissues, providing further support that these syndromic findings are a result of a multilineage somatic ras mutation.
5% of the patients with hypophosphatemia
were still under the treatment of PBs [Figure 1].
Authors noted that cardiac hypertrophy may be caused by hypophosphatemia
due to the low supply of phosphorus.
(plasma phosphate concentration < 1 mg/dL) is an extremely serious medical condition that can result in muscle weakness, mental status changes, rhabdomyolysis, and respiratory failure (1, 2).
Exclusion criteria were vitamin D supplementation in recent month, patients with renal failure, parathyroid disorders, pregnant women, disability, sarcoidosis, rickets and hypophosphatemia
, heart valve surgery, Rheumatic and Nonrheumatic Valvular Heart Disease ([greater than or equal to]moderate), Redo operation and patients with a history of AF.
M2 EQUITYBITES-July 29, 2016-Ultragenyx concludes X-Linked Hypophosphatemia
adult patient admission in Phase 3 Study of KRN23