It has a complete immune system with a diverse antibody repertoire and generates antibodies with human idiotypes
as effectively as wild-type animals make rat antibodies.
Traditional local genotypes appear to make idiotypes
in ours conditions culture .
This approach is based on the immune network theory of Jerne (1974), who proposed that the immune system is a network of interacting idiotypes
that is involved in the regulation of immune responses.
It has a complete immune system with a diverse antibody repertoire and is genetically engineered to produce antibodies with human idiotypes
Specific antibodies have repeated (cross-reacting, or general) idiotypes
and so-called private idiotypes
are unique amino acid sequences in the variable regions of antibodies.
OMT's genetic engineering is based on an improved understanding of B cell development and a new approach to inactivation of endogenous antibody expression, which enables OmniRat to make antibodies with human idiotypes
as efficiently as wild type rats make normal antibodies.
located on light and heavy chains of human myeloma proteins characterized by monoclonal antibodies.