(redirected from Idiotypes)
Also found in: Medical, Encyclopedia.


The complete set of idiotopes contained within the variable region of a particular immunoglobulin molecule and making up the molecule's antigen binding site.

id′i·o·typ′ic (-tĭp′ĭk) adj.
id′i·o·ty′py (-tī′pē) n.


the unique part of an antibody
Mentioned in ?
References in periodicals archive ?
It has a complete immune system with a diverse antibody repertoire and generates antibodies with human idiotypes as effectively as wild-type animals make rat antibodies.
Traditional local genotypes appear to make idiotypes in ours conditions culture [3].
This approach is based on the immune network theory of Jerne (1974), who proposed that the immune system is a network of interacting idiotypes that is involved in the regulation of immune responses.
It has a complete immune system with a diverse antibody repertoire and is genetically engineered to produce antibodies with human idiotypes.
Specific antibodies have repeated (cross-reacting, or general) idiotypes and so-called private idiotypes.
Idiotypes are unique amino acid sequences in the variable regions of antibodies.
OMT's genetic engineering is based on an improved understanding of B cell development and a new approach to inactivation of endogenous antibody expression, which enables OmniRat to make antibodies with human idiotypes as efficiently as wild type rats make normal antibodies.
Private idiotypes located on light and heavy chains of human myeloma proteins characterized by monoclonal antibodies.