After describing the presence of these molecules as one proof of idiotypic
mimicry, the report states simply: "Data not shown.
Every B cell has unique immunoglobulins on the cell surface, and the idiotypic
antibodies found on the surface of malignant B cells are highly specific tumor markers.
The Immune Network Model is a probabilistic approach to idiotypic
interactions occur mainly in patients who have received treatment with animal immunoglobulins (5).
This is the first evidence that idiotypic
vaccination may improve survival of MCL, an aggressive B-cell subtype of non-Hodgkin's lymphoma for which there is no current consensus standard-of-care.
Some heterophilic antibodies can react with human and animal immunoglobulins by binding to epitopes located on either the F(ab) or Fc region, although in healthy persons there is a predominance of idiotypic
Self organization: the memory cells are organized into so-called idiotypic
network (a hypotheses stated by Jerne, 1974) that changes in time.
AltaRex has granted to Biomira a royalty-free, non-exclusive license, if and when this patent issues, in relation to antigen-based or idiotypic
Genitope's approach is based on the finding that even though each NHL patient's B-cell tumor expresses a unique idiotypic
surface immunoglobulin (the BCR), those immunoglobulins nevertheless have characteristics that are shared across predictable patient subsets.
It has been postulated that heterophilic antibodies may arise through immunization via the gastrointestinal tract or that they play a role in regulation of the immune system via idiotypic
network interactions (2,10).
Therefore, the interfering antibodies might be idiotypic
antibodies that bind to a unique idiotype present on the Elecsys anti-TSH antibodies but not on the Centaur and Architect antibodies.
Genzyme Transgenics is also developing idiotypic
vaccines in collaboration with the National Cancer Institute.