In order to simulate immune networks, a bio-inspired network model known as Idiotypic
network theory (INT) is used.
Previously, the TAAs presented by MHC-I molecules were categorized into different classes based on various molecular criteria such as whether or not they are: overexpressed or exclusively expressed by the cancer cells, encoded by tumorigenic transforming viruses, commonly expressed in fetal tissues and in cancer cells, commonly expressed by cancer cells and adult reproductive tissues such as testis and placenta, cancer histotype and differentiation lineage specific, or idiotypic
Structural diversity of antigen binding sites of antibodies is proved by their idiotypic
The mechanism of action of IVIg is not completely understood, but may be attributed to interaction or modulation with multiple immune pathways, such as synthesis and release of cytokines and cytokine antagonists, neutralization of circulating autoantibodies by idiotypic
antibodies in IVIg, functional blockade of Fc recep-tors on splenic macrophages, inhibition of complement-induced damage, and blockade of Fas receptors by anti-Fas antibodies present in IVIg (14), (15).
2005) An Idiotypic
Immune Network for Mobile Robot Control.
complementarity and antigen-bridging interactions in the anti-lysozyme response.
The Immune Network Model is a probabilistic approach to idiotypic
interactions occur mainly in patients who have received treatment with animal immunoglobulins (5).
This unprecedented finding, later dubbed idiotypic
mimicry, provided the central conclusion of the CELL paper.
This is the first evidence that idiotypic
vaccination may improve survival of MCL, an aggressive B-cell subtype of non-Hodgkin's lymphoma for which there is no current consensus standard-of-care.
That suggested that the idiotypic
determinants (idiotopes) are related to the anti-3-FL binding site.
Some heterophilic antibodies can react with human and animal immunoglobulins by binding to epitopes located on either the F(ab) or Fc region, although in healthy persons there is a predominance of idiotypic