Two different medications have proved useful in treatment--desmopressin acetate and imipramine
, as well as an electronic device that makes a bell ring when its sensor detects the first sign of moisture in the bedding.
For these patients, some doctors prefer to treat mild to moderate depressive episodes with lithium alone because of the possibility that conventional anti-depressant drugs such as imipramine
may trigger a hypomanic or manic attack.
The drugs that form the second line of treatment for NE include tricyclic antidepressants (TCA) such as imipramine
and anticholinergics such oxybutynin.
Concentration = imipramine
But only 39 percent of patients on St John's Wort suffered side effects such as dry mouth and sweats compared with 63 percent on imipramine
John's wort to be more effective than placebo and as effective as imipramine
As early as 1958, Roland Kuhn, the discoverer of imipramine
, had noted that some sexual perversions responded to imipramine
and that many patients, when they recovered, felt better than well.
The physician's first choice for treatment of burning leg or foot pain is usually one of the tricyclic drugs, such as amitriptyline or imipramine
As a result of intensive work illustrating the benefits of therapeutic drug monitoring (TDM) of antidepressant medications, the American Psychiatric Association task force on the use of laboratory tests in psychiatry recommended the clinical use of monitoring plasma concentrations of the TCAs imipramine
, desipramine, and nortriptyline (6).
Patients received 20-40 mg paroxetine once daily, 200-300 mg imipramine
once daily, or placebo.
>500 ng/mL Concentration = imipramine
Open-label trials have suggested a beneficial effect with in some cases with the use of gabapentin, amitriptyline, imipramine
, flunarizine, propranolol, verapamil and pregabalin (6).