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immunogenicity |
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Nektar Advanced PEGylation has the potential to improve the safety and efficacy of therapeutic agents by increasing drug circulation time in the bloodstream, decreasing immunogenicity and dosing frequency, increasing bioavailability and improving drug solubility and stability. Live, attenuated vaccines must be able to replicate to levels that elicit a protective immune response without causing disease in the host, so a balance of infectivity, level of attenuation, and immunogenicity must be achieved. Under the agreement, NIAID will conduct a Phase I, open-label, dose escalating study to evaluate the safety, tolerability and immunogenicity of both EBS-C12, which is a single protein targeting protection against GBS infection, and EBS-C12 in combination with EBS-A42. |
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