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ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile.
Statistically significant association between positive CD30 markers expressed in cancerous cells and monoclonality gene rearrangements in immunoglobulin genes was observed.
MSPrecise uses NGS to measure DNA mutations present in rearranged immunoglobulin genes in immune cells initially isolated from cerebrospinal fluid.
B lymphocytes rearrange the immunoglobulin genes starting with the heavy chains, followed by the kappa and lambda light chains.
1-3) Tests by polymerase chain reaction (PCR) using DNA extracted from the specimen as a template and primers for immunoglobulin genes are probably among the more commonly ordered molecular tests.
Their gene rearrangement patterns were defined by Southern blot analysis and PCR or reverse transcription-PCR (RT-PCR) using commercially available probes or primers for the immunoglobulin genes [IgJ.
Like all B-cell neoplasms, the B cells in LPL have clonally rearranged immunoglobulin genes.

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