On July 14, 2006, staggering paresis of the hind legs, incoordination
, and intermittent opisthotonos developed in a female barbary macaque (Macaca sylvanus).
Neurologic abnormalities were frequently identified, especially in great horned owls, and included head tremors (n = 17), ataxia (n = 13), head incoordination
(n = 7), torticollis (n = 3), nystagmus (n = 3), and head tilt (n = 3).
The most common side effects associated with retigabine to date include somnolence, dizziness, confusion, speech disorder, vertigo, tremor, amnesia, abnormal thinking, abnormal gait, paresthesia, diplopia, incoordination
, nervousness, abnormal vision, asthenia, headache, nausea and diarrhea.
Severe clinical disease developed in 2 Mongolia/05-inoculated wood ducks, characterized by cloudy eyes, ruffled feathers, rhythmic dilation and constriction of the pupils, severe weakness, incoordination
, tremors, and seizures (Figure 1).
The owners reported that over the preceding 12 months the bird's condition had deteriorated from a decrease in daily activity and intermittent incoordination
to the inability to stand without support.
During the following 10 hours, the bird exhibited tachypnea and showed progressive neurologic signs of weakness, incoordination
, tremors, and depression.
They exhibited signs of disease such as high fever, dyspnea, depression, and diarrhea, and nervous signs such as ataxia, incoordination
, and convulsions (Figure 3A).
A variety of neurologic symptoms, including incoordination
, tremors, head-shaking, and seizures, have been described in sheep, pigs, cattle, rabbits, and monkeys infected with T.
On day 6 postinoculation, this male appeared weak, and on day 8 it exhibited nervousness, anorexia, pendular head movements, marked incoordination
of the extremities, penile relaxation, teeth grinding, muscular tremors, restlessness, dyspnea, head shaking, excessive sweating, movement of the ears in all directions, circular walking, and blindness.
Moderate to severe ataxia, weakness, and rear limb incoordination
were the most consistent signs; fever was not.
Less frequent adverse events reported were dizziness, headache, pain, vasodilation, diarrhea, ataxia, euphoria, incoordination
, asthma, rash, abdominal pain, nervousness and rhinitis (1%-5%).
Support to the MoH/DRG Center/Healthcare Departments incoordination
of activities for the piloting of the DRG system.