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1. The earliest identified occurrence of a disease or disorder, usually as part of an epidemiological investigation of a patient population or a genetic study of a family.
2. The first patient who has such a disease or disorder. Also called proband, propositus.
(Medicine) med the first case of a disease, or the primary case referred to in a report
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|Noun||1.||index case - the earliest documented case of a disease that is included in an epidemiological study|
epidemiology - the branch of medical science dealing with the transmission and control of disease
patient - a person who requires medical care; "the number of emergency patients has grown rapidly"