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Characterization of a forest soil metagenome clone that confers indirubin and indigo production on Escherichia coli.
Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell.
Indirubin is a CDKI that has been used in traditional medicine for hundreds of years and is currently being used in clinical trials for CML (19).
3] This is excreted and broken down in the urine by bacteria possessing one or both enzymes, sulphatise and phosphatase that metabolize this pigment to indirubin and indigo in an alkaline environment (urine).
Solove Research Institute (OSUCCC - James) - discovered that the compound, indirubin, both blocks the migration of glioblastoma cells, preventing their spread to other areas of the brain, and the migration of endothelial cells, preventing them from forming the new blood vessels that the tumor needs to grow.
On extraction with solvents, a number of the darkly coloured sediments yielded vivid purple extracts, which were subsequently determined by a combination of high performance liquid chromatography (HPLC), mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR) to contain brominated derivatives of indigo and indirubin (see Technical Note, below).
Scientists have discovered that indirubin is able to help block the division of cancerous cells, which could give the plant a whole new future.
Laurent Meijer, of the Roscoff Biological Station in France, found the active ingredient was a red pigment called indirubin which reduces the protein needed when cells multiply.
Indirubin (CAS 479-41-4) Market Research Report 2009
Indigo naturalis and its active component, indirubin, have been used for decades in China to treat systemic psoriasis and leukemia (Xiao et al.
Kaempferol, tryptanthrin, and indirubin are natural constituents from the NJJ (Kataoka et al.
trunculus where the secretion contains both brominated and nonbrominated dye precursors and because of cross coupling of different indoxyl or indoleninone chromogens leading to a mixture of a high concentration of 6-bromoindigo with indigo, indirubin and dibromoindigo (Wouters 1992, Koren 1994, Cooksey 2001).
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