Also provided are methods of inhibiting
HIV-1 production in a cell, or spread of the HIV-1 to another cell, by treating the cells with the above peptides or vectors.
NS1 of influenza A virus, but not of influenza B virus, inhibits cellular factors involved in mRNA processing (22,23); this function might also play a role in inhibiting
IFN[alpha]/[beta] production by influenza A virus (24).
A search for drugs inhibiting
the binding of CILP to TGF-[beta]1 will be a key to develop this treatment," says Junya Toguchida of Kyoto University in Japan.
Because cell biology studies indicate that many metal compounds enhance the genotoxic effects of known mutagens such as ultraviolet C radiation, X rays, benzo[a]pyrene, cisplatin, and DNA alkylating agents, it has been postulated that environmental metals are comutagenic and potentiate the carcinogenic effects of DNA-damaging agents by inhibiting
DNA repair processes (Hartwig et al.
Recent findings have shown that inhibiting
gastrin not only inhibits cell growth, proliferation and metastasis directly, but also "unblocks" a central pathway leading to cell-suicide (apoptosis).
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) work to reduce pain and inflammation by inhibiting
prostaglandins (see Running & FitNews, January 1999).
Microban is registered by the EPA as inhibiting
bacterial growth in plastic but has not been approved for public health claims for humans, the EPA said.
The determination of the safety and effectiveness of ADCON(R)-T/N (tendon/peripheral nerve) in inhibiting
peritendinous adhesions will be the subject of a Phase II SBIR grant.
Gore & Associates (Gore) today announced that laboratory results show GORE DUALMESH([R]) PLUS Biomaterial is the only hernia repair material inhibiting
bacterial colonization of the device for up to 14 days post-implantation and the only prosthetic patch resisting initial biofilm formation over the same period of time.
2] was killing the parasite by inhibiting
TbcatB, the researchers interfered with the cellular mechanisms that underlie TbcatB's manufacture.
This study, and earlier work by the same team, demonstrates that procyanidin B dimers in red wine could be used as chemopreventive agents against breast cancer by inhibiting
the conversion of androgens to estrogens in breast tissue.
This invention provides a method of inhibiting
PAK4 function comprising administering a ligand comprising an amino acid domain which binds to a GTP binding protein so as to inhibit binding of the GTP binding protein to PAK4.