interferon


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Related to interferon: interleukin

in·ter·fer·on

 (ĭn′tər-fîr′ŏn′)
n.
1. Any of a group of glycoproteins that are produced by different cell types in response to various stimuli, such as exposure to a virus, bacterium, parasite, or other antigen, and that inhibit infection through mechanisms such as preventing viral replication or regulating the immune system.
2. Any of a group of synthetic glycoproteins that are structurally similar to these compounds and are used therapeutically, especially as antivirals.

interferon

(ˌɪntəˈfɪərɒn)
n
(Biochemistry) biochem any of a family of proteins made by cells in response to virus infection that prevent the growth of the virus. Some interferons can prevent cell growth and have been tested for use in cancer therapy
[C20: from interfere + -on]

in•ter•fer•on

(ˌɪn tərˈfɪər ɒn)

n.
any of various proteins, produced by virus-infected cells, that inhibit reproduction of the invading virus and induce resistance to further infection.
[1957; interfere + -on1]

in·ter·fer·on

(ĭn′tər-fîr′ŏn′)
Any of a group of proteins that are produced by animal cells in response to infection by a virus and that, in many cases, prevent replication of the virus. Some interferons trigger an immune response in the body. They have been investigated as treatment for many diseases, including certain cancers.

interferon

Immune system proteins that help to protect cells against attack by some kinds of viruses.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.interferon - an antiviral protein produced by cells that have been invaded by a virus; inhibits replication of the virus
alpha-interferon - a form of interferon that is produced endogenously and commercially for its pharmacological effects (including regulation of the immune system and antiviral and antineoplastic effects)
antiviral, antiviral agent, antiviral drug - any drug that destroys viruses
beta-interferon - a form of interferon that is produced by fibroblasts and have antiviral effects; used in the treatment of multiple sclerosis
gamma-interferon - a form of interferon that is produced by T cells and macrophages; involved in the activation of phagocytes
Translations

interferon

[ˌɪntəˈfɪərɒn] Ninterferón m

interferon

n (Chem) → Interferon nt

in·ter·fer·on

n. interferón, proteína natural liberada por células expuestas a la acción del virus que se usa en el tratamiento de infecciones y neoplasmas.

interferon

n interferón m; alpha (beta, etc.) interferon interferón alfa (beta, etc.); pegylated — interferón pegilado
References in periodicals archive ?
Majority Interferon Drugs in Preclinical Phase: 29 Drugs
The most commonly reported adverse reactions (at least 5% more frequent on interferon beta-1b than on placebo) in controlled clinical trials were injection site reaction (78% vs 26% for placebo), lymphopenia (86% vs 66%), flu-like symptoms (57% vs 37%), myalgia (23% vs 14%), leukopenia (13% vs 4%), neutropenia (13% vs 5%), increased liver enzymes (SGPT to greater than five times baseline value[12% vs 4%], SGOT to greater than five times baseline value[4% vs 1%]), headache (50% vs 43%), hypertonia (40% vs 33%), pain (42% vs 35%), rash (21% vs 15%), insomnia (21% vs 16%), abdominal pain (16% vs 11%), and asthenia (53% vs 48%).
Indeed, interferon has been called "evolution's first and perhaps most important invention for the survival of animals.
Kaye said that by that time, Yamanouchi's rights to market another interferon drug, known as Intron in the U.
They say the mistake was to assume that the benefits of beta interferon do not extend beyond about two years.
Plantation, FL; 954-233-8746) announced it has been granted United States Patent 6,350,589 from the United States Patent and Trademark Office for a process relating to the manufacture of human natural alpha interferon from human white blood cells.
Favorable long-term tolerability, depression of MRI T2 lesion burden, and the disappearance of neutralizing antibodies are reassuring to patients who have begun long-term treatment programs with interferon beta-1b.
Only long-term follow-up of patients in this and other studies will reveal whether the drug can keep CML at bay indefinitely and continue to spare patients the side effects that have plagued interferon therapy, Hoffman says.
The investigator-initiated study, conducted by researchers from the University of Tubingen in Germany, showed that at the end of 72 weeks of daily therapy, the majority of patients treated with a combination of either consensus interferon plus ribavirin or pegylated interferon alfa-2a plus ribavirin had a reduction in hepatitis RNA.
In preclinical studies, Biolex has shown that BLX-883 is comparable to commercially available alfa interferon and that it can be produced cost-effectively using Biolex' proprietary LEX System in the company's cGMP manufacturing facilities.
At the end of the study follow-up, since disease activity resumed in most patients receiving the interferon beta-1a regimen," Prof.
Infergen or consensus interferon is a bio-optimized, selective and highly potent type 1 interferon alpha originally developed by Amgen and launched in the United States in 1997.

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