internucleotide

internucleotide

(ˌɪntəˈnjuːklɪəˌtaɪd)
adj
(Biochemistry) biochem occurring or existing between nucleotides
References in periodicals archive ?
Synthego's modified sgRNA are synthesized with 2'-O-methyl analogs and 3' phosphorothioate internucleotide linkages in the first three nucleotides at both the 5' and 3' end of the RNA molecule.
2 --O--R (SEQ ID NO:1), wherein X is an internucleotide linkage of type o or s, with the proviso that x is an s linkage at least 4 times and at most 9 times, and o means a phosphodiester internucleoside linkage, s means a phosphorothioate internucleoside linkage, R means a C.
Solid-phase synthesis of oligodeoxynucleotides containing phosphoramidite internucleotide linkages and their specific chemical.
GRN163 is a novel short oligonucleotide with modified internucleotide linkages.
The newly issued patent is an extension of previously issued patents (United States Patent 5,652,355, 6,143,881 and 6,346,614) and claims oligonucleotides comprising a deoxyribonucleotide, a 2'-substituted ribonucleotide, and a phosphorothioate or phosphorodithioate internucleotide linkage, where the 2'-substitution is either 2'-O-aryl ribonucleotide or a 2'-O-amino ribonucleotide.