Effects of age and interstimulus
interval on the brainstem auditory evoked potential.
In paired-pulse TMS stimulation studies, the test stimuli are given at supra-threshold intensities, and the effect of a subthreshold conditioning stimuli that are given before the test stimuli with predetermined interstimulus
intervals (ISI) on the motor responses evoked by the test stimuli are studied.
In their study, Perez and her co-authors, departmental colleagues Jinyi Long, PhD, and Paolo Federico, PhD, used 180 pairs of noninvasive transcranial magnetic stimulation for 30 minutes over the hand representation of the primary motor cortex at an interstimulus
interval, which is the time interval between the termination of one stimulus and the beginning of another, mimicking the rhythm of descending late indirect (I) waves in corticospinal neurons or at an interstimulus
interval in between I-waves as a control protocol.
However, those results were not reproduced when the standard interstimulus
interval (ISI) of 500 ms was changed to 2,000 ms (Lee & Shafran, 2008).
To equate interstimulus
intervals, the next trial began after 8.
05 ms, interstimulus
interval: 4 ms, intensity: 380 V) and were bilaterally recorded by needle electrodes (12 mm) on the abductor pollicis brevis, tibialis anterior and abductor hallucis muscles.
Concomitant heart rate and eyeblink Pavlovian conditioning in human subjects as a function of interstimulus
Each trial was presented sequentially in a pseudorandom order during 2000 ms with an interstimulus
interval of 2100 ms.
Two series of30 laser pulses were applied to the dorsum of the right hand, with an interstimulus
interval of 10 sec and an interseries interval of at least 5 min.
Effects of interstimulus
interval length and variability on startle-response habituation in the rat.
interval ranged from 500 to 1000 ms.
This variability included, but was not limited to: the stimulus intensity and interstimulus
interval of the peripheral evoked potentials, the impedance and location of recording electrodes, the number of signals recorded to generate an average waveform, the filtering and amplification of recorded signals, and the measurement and recognition of specific peaks.