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intranuclear |
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| We suspected a malignancy, but histopathology of biopsy specimens revealed that the mass exhibited the classic signs of the HSV cytopathic effect, including the presence of intranuclear inclusion bodies, ballooning degeneration of epithelial cells, and a ground-glass appearance of some nuclei. Typical intranuclear inclusions were found by histologic analysis, and poxlike particles were found by transmission electron microscopy of 6 biopsy specimens from buccal lesions of the same animals. Several proteins, such as the tumor suppressor p53-binding protein 1 (53BP1) and phosphorylated H2AX ([gamma]-H2AX), have been shown to produce discrete intranuclear loci, which are believed to colocalize with DNA double-strand breaks (DSBs) providing a scaffold structure for DSB repair (DiTullio et al. |
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