According to the FDA, clinical signs of ionophore
poisoning in horses vary depending on the dosage ingested, but can include poor appetite and feed refusal of the grain product, diarrhea, weakness, rapid heart rate, labored breathing, decreased exercise tolerance, depression, wobbly gait, colic, sweating, recumbency, and sudden death.
12) In a second experiment, glial cells were also protected from programmed cell death by overproduction of calbindin D-29K when exposed to a calcium ionophore
or the amyloid-beta peptide of Alzheimer's disease, both of which promote cell death by calcium dysregulation.
According to Waldrip, Zoamix is unique in that it s a synthetic compound but works similarly to an ionophore
by allowing some cycling of Eimeria, the parasite that causes coccidiosis.
5 [micro]g/mL calcium ionophore
, and 1 [micro]g/mLGolgiPlugfor 5 h at 37[degrees]C in a humidified atmosphere with 5% C[O.
Purified peritoneal mast cells were preincubated in the presence of test compounds (hydroxytyrosol or oleuropein), before incubation with concanavalin A, compound 48/80 or calcium ionophore
Effect of phloretin on ionophore
mediated electroneutral transmembrane translocations of [H.
Food safety advocates may be concerned about the potential for ionophore
supplements to contribute to antibiotic resistant bacteria that could infect humans.
This was followed by restimulation with PMA and calcium ionophore
Vasodilatory response to bradykinin and calcium ionophore
was significantly impaired in animals with HC+HT compared with each risk factor alone (P<0.
Vaccines composed of either virulent or attenuated Eimeria species oocysts have been developed as an alternative to medication of feed with ionophore
drugs or synthetic chemicals.
In recent reports 5-CHQ have been demonstrated to act as Zinc ionophore
and to induce apoptosis of human cancer cells.
At pH 5, the extract inhibited 1-diphenyl-2-picrylhydrazyl (DPPH) free radicals and suppressed nitric oxide and [beta]-hexosaminidase from lipopolysaccharide (LPS)-induced mouse macrophage leukemia cells and ionophore
A23187-stimulated rat basophilic cells.