iproniazid


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iproniazid

(ˌaɪprəˈnaɪəˌzɪd)
n
(Recreational Drugs) a derivative of isoniazid which was formerly used as an antidepressant and to treat tuberculosis. Formula: C9H13N3O
References in periodicals archive ?
The earliest MAOI, iproniazid, was a hydrazine derivative and exhibited hepatotoxicity, (13) as did certain other hydrazine MAOIs.
Several classes of antidepressants owe their discovery to chance, from iproniazid, which was initially used to treat tuberculosis in the 1950s, to the tricyclics of the 1960s, which stemmed from an experimental treatment for schizophrenia and the more recent breakthrough involving the use of ketamine .
Only the comparison with a rather "historical" MAO-inhibitor, iproniazid, that exhibited very poor affinity for the enzymes when compared with novel generation of MAO blockers permitted consideration of the MAO inhibition by 10-100 [micro]M resveratrol of relevant interest [2].
In 1952, doctors noted that patients on the antituberculosis drug iproniazid became euphoric.
The urinary excretion of adrenaline and noradrenaline by depressive patients during iproniazid treatment.
Toxic effect of iproniazid in a patient with angina.