2) The Sequenced Treatment Alternatives to Relieve Depression (STARED) study demonstrated that <50% of MDD patients achieve remission in monotherapy trials of selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, mirtazapine, or bupropion, necessitating consideration of antidepressant combinations, augmentation options, and eventually irreversible, nonselective MAOIs such as phenelzine, tranylcypromine, or isocarboxazid
Monoamine phenelzine (Nardil); Increase oxidase tranylcypromine (Parnate); norepinephrine, inhibitors isocarboxazid
(Marplan) serotonin, and (MAOIs) dopamine.
5 75-225 Serotonin modulators Trazodone 50 75-400 Norepinephrine-serotonin modulator (NaSSA) Mirtazapine 15 15-45 Monoamine oxidase inhibitors (MAOIs) Irreversible, nonselective Phenelzine 15 15-90 Tranylcypromine 10 30-60 Isocarboxazid
20 30-60 Reversible MAOI-A Moclobemide 300 300-600 Melatonergic agonist Agomelatine 25 25-50 * Reprinted with permission from APA Practice Guideline for the Treatment of Patients with Major Depressive Disorder, 3rd ed, [c] 2010).
They include phenelzine (Nardil), isocarboxazid
(Marplan) and tranylcypromine (Parnate).
A recent meta-analysis (2) found no benefit over placebo of the ADs paroxetine, fluoxetine, amitriptyline and isocarboxazid
- studied specifically in patients with 'minor' depression.
MAO inhibitor antidepressants (for example, isocarboxazid
1A] receptor agonist used for anxiety) may interact with monoamine oxidase inhibitors (MAOIs), such as isocarboxazid
, phenelzine, and tranylcypromine.
, tranylcypromine) potentiate brain amine levels by inhibiting the breakdown of brain amines.
The first-generation MAOIs such as phenelzine and isocarboxazid
were largely nonselective inhibitors of both subtypes of MAO, MAO (A) and MAO (B).
PHILADELPHIA--The monoamine oxidase inhibitor isocarboxazid
may be an effective migraine preventive as well, Dr.