isocarboxazid


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Related to isocarboxazid: Linezolid, Selegiline, tranylcypromine

i·so·car·box·a·zid

 (ī′sō-kär-bŏk′sə-zĭd)
n.
A monoamine oxidase inhibitor, C12H13N3O2, used as an antidepressant.

[Shortening and rearrangement of isoxazolylcarbonyl, one of its constituents + (hydr)azid(e), one of its constituents; see isoniazid.]

isocarboxazid

(ˌaɪsəʊkɑːˈbɒksəzɪd)
n
(Recreational Drugs) an antidepressant that is derived from hydrazine. Formula: C12H13N3O2
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.isocarboxazid - a monoamine oxidase inhibitor (trade name Marplan) that is used to treat clinical depressionisocarboxazid - a monoamine oxidase inhibitor (trade name Marplan) that is used to treat clinical depression
MAOI, monoamine oxidase inhibitor - any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate
References in periodicals archive ?
5 75-225 Serotonin modulators Trazodone 50 75-400 Norepinephrine-serotonin modulator (NaSSA) Mirtazapine 15 15-45 Monoamine oxidase inhibitors (MAOIs) Irreversible, nonselective Phenelzine 15 15-90 Tranylcypromine 10 30-60 Isocarboxazid 20 30-60 Reversible MAOI-A Moclobemide 300 300-600 Melatonergic agonist Agomelatine 25 25-50 * Reprinted with permission from APA Practice Guideline for the Treatment of Patients with Major Depressive Disorder, 3rd ed, [c] 2010).
A recent meta-analysis (2) found no benefit over placebo of the ADs paroxetine, fluoxetine, amitriptyline and isocarboxazid - studied specifically in patients with 'minor' depression.
phenelzine, isocarboxazid, tranylcypromine) potentiate brain amine levels by inhibiting the breakdown of brain amines.