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isoflurane |
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| Although he had been exposed to isoflurane, an anesthetic agent that predisposes patients to malignant hyperthermia, initial signs of PRIS appeared on the third day following surgery, and the patient did not show all the signs and symptoms of malignant hyperthermia. For intervention, animals were anesthetized with inhalation of 3% isoflurane ([dagger][dagger]) at 1. Ten inbred, 7-week-old SJL/OlaHsd (Harlan, Bicester, UK) female mice closely related to the SJL/J strain, which develops spontaneous B-cell lymphomas at [greater than or equal to] 8 months of age (8,9), were intracerebrally injected under isoflurane anesthesia with 1% vCJD human brain homogenate (World Health Organization reference material) (1 O) diluted in physiologic saline, while 4 control animals received physiologic saline only. |
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