A review of her medical records showed that she was treated for pulmonary TB at the age of 40, with a 1-year course of isoniazid
, ethambutol, and streptomycin, and was kept in a sanitarium for some time.
9] demonstrated that a three-drug prophylactic regimen consisting of high-dose isoniazid
, of loxacin and ethambutol for 6 months was both effective and well tolerated in child contacts of MDR-TB; only 3.
These patients were given routine first-line treatment, consisting of isoniazid
, rifampin, pyrazinamide, and ethambutol during a 2-month intensive phase followed by isoniazid
and rifampin during a 4-month continuation phase.
A recent evaluation of the MTBDRplus assay for detection of drug resistance showed that use of a multiplex polymerase chain reaction amplification step as part of extracting DNA from slides resulted in a sensitivity of detecting isoniazid
resistance of approximately 80%, and a sensitivity of approximately 98% for detecting rifampin resistance, and a sensitivity of approximately 83% of detecting MDR-TB.
9 percent of ordinary, actively replicating TB bacteria within three weeks, and in combination with isoniazid
or rifampin, could kill 100 percent within that period.
12), (13) Unlike Xpert[R] MTB/RIF, however, it requires formal laboratory infrastructure, but has the advantage of testing for both rifampicin and isoniazid
We predicted that if we added isoniazid
and cysteine to isoniazid
In March 2006, he was readmitted to the hospital for worsening of his condition and onset of side effects associated with rifampin and isoniazid
To test this hypothesis, we repeated the experiment using isoniazid
and a different reducing agent- vitamin C," said Dr.
SIDEBAR] About Drug-Resistant TB Multi-drug-resistant TB (MDR-TB): TB that does not respond to isoniazid
and rifampicin, the two most potent anti-TB drugs.
Plus, every year 500,000 people are infected by bacteria that are impervious to isoniazid
and rifampin, the most widely used first-line treatments for TB, according to (http://www.
Effect of isoniazid
prophylaxis on mortality and incidence of tuberculosis in children with HIV: randomised controlled trial.