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Related to isoniazid: Pyrazinamide


A crystalline antibacterial compound, C6H7N3O, used in the treatment of tuberculosis.

[isoni(cotinic acid), isomer of nicotinic acid (iso- + nicotinic acid) + (hydr)azid(e), one of its constituents (hydr(o)- + az(o)- + -ide).]


(ˌaɪsəʊˈnaɪəzɪd) or


(Pharmacology) a soluble colourless crystalline compound used to treat tuberculosis. Formula: C6H7N3O
[C20 isoni(cotinic acid hydr)azid(e)]


(ˌaɪ səˈnaɪ ə zɪd)

a water-soluble solid, C6H7N3O, used in the treatment of tuberculosis.
[1950–55; short for isonicotinic acid hydrazide]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.isoniazid - antibacterial drug (trade name Nydrazid) used to treat tuberculosis
antibacterial, antibacterial drug, bactericide - any drug that destroys bacteria or inhibits their growth

isoniazid (INH)

n isoniazida
References in periodicals archive ?
A review of her medical records showed that she was treated for pulmonary TB at the age of 40, with a 1-year course of isoniazid, ethambutol, and streptomycin, and was kept in a sanitarium for some time.
9] demonstrated that a three-drug prophylactic regimen consisting of high-dose isoniazid, of loxacin and ethambutol for 6 months was both effective and well tolerated in child contacts of MDR-TB; only 3.
These patients were given routine first-line treatment, consisting of isoniazid, rifampin, pyrazinamide, and ethambutol during a 2-month intensive phase followed by isoniazid and rifampin during a 4-month continuation phase.
A recent evaluation of the MTBDRplus assay for detection of drug resistance showed that use of a multiplex polymerase chain reaction amplification step as part of extracting DNA from slides resulted in a sensitivity of detecting isoniazid resistance of approximately 80%, and a sensitivity of approximately 98% for detecting rifampin resistance, and a sensitivity of approximately 83% of detecting MDR-TB.
9 percent of ordinary, actively replicating TB bacteria within three weeks, and in combination with isoniazid or rifampin, could kill 100 percent within that period.
12), (13) Unlike Xpert[R] MTB/RIF, however, it requires formal laboratory infrastructure, but has the advantage of testing for both rifampicin and isoniazid resistance.
We predicted that if we added isoniazid and cysteine to isoniazid-sensitive M.
In March 2006, he was readmitted to the hospital for worsening of his condition and onset of side effects associated with rifampin and isoniazid use.
To test this hypothesis, we repeated the experiment using isoniazid and a different reducing agent- vitamin C," said Dr.
SIDEBAR] About Drug-Resistant TB Multi-drug-resistant TB (MDR-TB): TB that does not respond to isoniazid and rifampicin, the two most potent anti-TB drugs.
Plus, every year 500,000 people are infected by bacteria that are impervious to isoniazid and rifampin, the most widely used first-line treatments for TB, according to (http://www.
Effect of isoniazid prophylaxis on mortality and incidence of tuberculosis in children with HIV: randomised controlled trial.