isoprenaline


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Related to isoprenaline: propranolol, atropine

isoprenaline

(ˌaɪsəʊˈprɛnəˌliːn) or

isoproterenol

n
(Recreational Drugs) drugs a compound that is a derivative of adrenaline and that is used to treat asthma and bronchial conditions. Formula: C11H17NO3
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An epidemic of asthma deaths in a number of countries, including New Zealand and Australia, but not the United States (US), occurred with the introduction of isoprenaline forte in the 1960s.
However, SH rats have greater increases in BP in response to adrenalin (Yamaguchi and Kopin 1980) and proportional increases in BP in response to isoprenaline (Weinstock and McCarthy 1983) compared with WKY rats and hence might have had a higher peak BP response than WKY rats during dobutamine administration despite the preexisting hypertension.
It is widely advocated to have an infusion of isoprenaline available in case intraoperative ST segment changes occur (15,17,19,21,22,24,27).
30-33) Lonnrot et al (34) found that in isolated mesenteric arterial rings isolated from aged Wistar rats, long-term dietary CoQ supplementation enhanced endothelium-independent arterial relaxation in response to isoprenaline and improved the endothelium-dependent vasodilation response to acetylcholine (ACh) in arterial rings precontracted with noradrenalin.
Tracheal responsiveness to both isoprenaline and beta2-adrenoreceptor blockade by propranolol in cigarette smoke exposed and sensitized guinea pigs.
It did not respond to intravenous atropine, mephentermine, isoprenaline, dopamine and adrenaline infusions.
Administration of Isoprenaline in the presence and absence of Beta1 and Beta2 adrenergic receptor antagonists showed that hESC-derived cardiomyocytes are comparable to adult human ventricular myocytes in that Isoprenaline responses can be mediated by both Beta1 and Beta2 adrenergic receptors.
Then 60 SD rats were randomly divided into five groups: (1) a normal control group, (2) an isoprenaline (ISO)-induced myocardial ischemic model group, (3) a TPG treatment group (TPGs 269.