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isotretinoin

   Also found in: Medical, Wikipedia 0.02 sec.
i·so·tre·ti·noin  (s-trtn-oin)
n.
A synthetic retinoid, C20H28O2, that inhibits sebaceous gland secretion and is used in the treatment of severe forms of acne.
[iso- + tretinoin, retinoic acid (t(rans)- + retino(ic acid) + -in).]
isotretinoin [ˌaɪsəʊtrəˈtɪnəʊɪn]
n
(Medicine / Pharmacology) a drug related to vitamin A, used to treat severe acne that has failed to respond to other treatment


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However, anecdotal complaints linking isotretinoin to depression and suicide have left some doctors and patients concerned about the drug's safety.
Acne drug affects brain function by Science News
In utero exposure to isotretinoin (13-cisretinoic acid), an analog of vitamin A used to treat cystic acne, is associated with a characteristic pattern of malformations, including abnormal ear development, a flat nasal bridge, mandibular hypoplasia, cleft palate, hydrocephalus, neural tube defects, and conotruncal heart defects (Lammer et al.
Children's health and the environment: public health issues and ... by Eskenazi, Brenda / Environmental Health Perspectives
For patients with severe inflammatory acne that does not improve with other medications, such as those described above, isotretinoin (Accutane), a retinoid, may be needed.
Questions and Answers About Acne by Pamphlet by: Nat'l Inst. of Arthritis and Musculoskeletal & Skin Diseases
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