Pulmatrix announced that the single dose escalation phase of the first-in-human study for Pulmazole- an inhaled iSPERSE formulation of the anti-fungal drug itraconazole
for the treatment of allergic bronchopulmonary aspergillosis in patients with asthma - has commenced.
An Etest was used in accordance with the manufacturer's instructions to specify the amphotericin B (AMB), fluconazole, voriconazole, ketoconazole, itraconazole
, anidulafungin, caspofungin, and flucytosine (FLU) susceptibilities of the species.
Objective: To compare the efficacy of single dose of oral itraconazole
400mg with 1% topical clotrimazole in the treatment of pityriasis versicolor.
and voriconazole concentrations were also inconsistent and did not reach targeted concentrations.
17%) were confirmed to be itraconazole
resistant, with MICs of ≥8 mg/L, and one isolate (0.
Drug susceptibility was assessed using FUNGITEST[R] (Sanofi Diagnostics Pasteur) for the analysis of fungal growth in the presence of six drugs, such as 5-fluorocytosine, amphotericin B, miconazole, ketoconazole, itraconazole
and fluconazole used at two concentrations, in modified RPMI 1640 medium, in the presence of a redox indicator.
28) was the use of pulsed itraconazole
4 Alternative therapies include itraconazole
200 mg once daily for three days.
A previous in vitro investigation found that a sinergistic effect might occur, when using itraconazole
(ITRA) and ritonavir (RTV) against Histoplasma capsulatum, (1) where an interesting mechanism of action was proposed.
Treatment was instituted with oral Itraconazole
, but dog died owing to severe epistaxis.
WAIKOLOA, HAWAII -- The familiar oral triazole antifungal agent itraconazole
is under active investigation for an unexpected use: as adjunctive therapy in patients with locally advanced or metastatic basal cell carcinoma.
Clinically, we suspected and confirmed chromoblastomycosis based history of trauma, farmer by occupation, on hypertrophic verrucous nature of the disease, satellite lesions, black dots, sclerotic cells, elliptical conidia on LCB mount, black growth on SDA, favourable response to itraconazole
and ruled out phaeohyphomycosis, mycetoma.