Clinicians should be vigilant in diagnosing and treating fungal keratitis
, and users of MoistureLoc should discontinue the use of this product," the CDC investigators said (JAMA 2006;296:953-63).
Federal, state, and local health officials are investigating at least 109 cases of Fusarium keratitis
in which the use of a contact lens solution may have played a role.
The source of an apparent spike in Fusarium keratitis
infections linked to the ReNu with MoistureLoc contact-lens solution remains unknown, and it could be weeks before an explanation is found, its chief executive, Ron Zarrella, said Wednesday.
Recently, reports have surfaced that saprobic fungi, as well as fungi pathogenic for plants, have evolved as human pathogens; reported cases have involved skin infections, endocarditis, brain abscess, onychomycosis, keratitis
, mycetoma, bronchopulmonary disease, and rhinosinusitis.
caused by bacteria is the most serious response seen during lens wear (1 in 1000 wearers) and can lead to vision impairment and, in serious cases, to permanent vision loss.
has received a $100,000 grant from the National Eye Institute, a member agency of the National Institute of Health, to study the use of ECI developed Protector Proteins to combat microbial keratitis
Recently, contact lens solutions containing ethyl mercury (thimerosal) caused blepharoconjunctivitis and punctate keratitis
in many contact lens wearers.
The condition, known as keratitis
, is caused by the water-borne amoeba acanthamoeba, which causes ulcers on the cornea.
occurs when the virus invades the inner layer of the eye's cornea where it can lead to scarring and loss of vision.
The study's investigation demonstrated that the risk of developing ulcerative keratitis
(inflammation of the cornea) is four to five times greater for extended-wear contact users than for daily-wear users.
It also reviews key players involved in the therapeutic development for Keratitis
This gives patients across England and Wales access to the first and only eye drops licensed for the treatment of severe keratitis
in patients with dry eye disease in the UK.