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keratoacanthoma |
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To date, MCPyV has been most commonly studied and detected in the context of Merkel cell carcinoma (3,7), but it has also been identified in Kaposi sarcoma tissue (3), primary squamous cell carcinoma tissue (7), keratoacanthoma tissue from an organ recipient (8), in normal sun-exposed skin (7), and in a small number of control tissues (normal skin, small bowel, hemorrhoids, appendix, and gall bladder) (3). In a 2-year dermal carcinogenicity study in rats, treatment with BenzaClin Topical Gel at doses of 100, 500, and 2000 mg/kg/day caused a dose-dependent increase in the incidence of keratoacanthoma at the treated skin site of male rats. keratoacanthoma, and polychondritis secondary to an autoimmune disease. |
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