The team hypothesises that similarly structured beta lactones
could "mask" themselves as mycolic acid to enter the mycolic acid metabolic pathways and then block the decisive enzymes.
The non-compliance rates for resorcylic acid lactones
(hormonally active compounds produced by fungi or man-made) and contaminants such as metals and mycotoxins (toxins produced by fungi) were higher than for other groups of substances, but slightly down on the previous report.
family Asteraceae) has stood out in previous studies for its allelopathic potential, due to the sesquiterpene lactones
(glaucolide B) (Padolina et al.
One of the most well studied QS signal molecules (autoinducer) are A-acylhomoserine lactones
Summary: Sesquiterpene lactones
(SLs) with various activities, which are primarily composed of enhydrin, are the primary constituents in the leaves of the yacon, Smallanthus sonchifolius (Peoepp.
Methods: ALCL, leukaemia and breast cancer cells, and normal peripheral blood mononuclear cells (PBMCs) were treated with isolated sesquiterpene lactones
and analysed for cell cycle progression, proliferation, mitochondrial activity, apoptosis, protein and mRNA expression, NF-[kappa]B and cytochrome P450 activity, 12(S)-HETE production and lymphendothelial intravasation.
Important wood chemicals, which could be supposed to be impact molecules, include naturally present cis and trans methyl-octalactone (whisky lactones
, with a coconut flavor in pure state), trans-2-nonenal (sawdust smell), toasting releasing volatile phenols: guaiacol, 4-methyl-guaiacol and eugenol (spicy and smoky smells) and vanillin (vanilla smell).
Self Perception in Bacteria: Quorum Sensing with Acylhomoserine Lactones
immitis resistance to macrocyclic lactones
, such as ivermectin, for heartworm chemoprophylaxis.
Boll PM, Sorenson E, Balieu E: Naturally occurring lactones
hysterophorus responsible for ABCD are sesquiterpene lactones
(SLs) consisting of a lactone
ring attached to a sesquiterpene.
In the majority of gram negative bacteria quorum sensing is mainly mediated by signaling cascades, involving N-acyl-homoserine lactones
(AHLs) (Von Bodman et al.