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lentivirus |
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Since ongoing lentivirus emergence would be of substantial importance to global public health, we looked for evidence of SIV in a unique collection of plasma from persons with known levels of exposure to the blood and body fluids of NHPs (3). Indeed, SIV-infected sooty mangabeys may be spared, by their failure to mount significant antiviral immune responses, much of the indirect bystander damage seen in pathogenic primate lentivirus infections that both contributes to accelerated CD4 depletion and compromises host immune regenerative capacity. Scientists also can engineer the property into other viruses, such as poliovirus, herpesvirus, adenovirus, and a candidate currently being tested, a lentivirus derived from HIV. |
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