leukotriene


Also found in: Medical, Acronyms, Encyclopedia, Wikipedia.

leu·ko·tri·ene

 (lo͞o′kə-trī′ēn)
n.
Any of several lipid compounds that contain 20 carbon atoms, are related to prostaglandins, and mediate the inflammatory response.

[leuko(cyte) + triene, a compound containing three double bonds (tri- + -ene).]

leukotriene

(ˌluːkəʊˈtraɪiːn)
n
(Biochemistry) one of a class of products of metabolic conversion of arachidonic acid; the active constituents of slow-reacting substance, responsible for bronchial constriction, contraction of smooth muscle, and inflammatory processes
[C20: from leukocyte, in which they were discovered + triene from the conjugated triene unit that they contain]

leu•ko•tri•ene

or leu•co•tri•ene

(ˌlu kəˈtraɪ in)

n.
a lipid, C20H30O3, produced by white blood cells in an immune response to antigens, that contributes to allergic asthma and inflammatory reactions.
[1975–80; leuko- + triene (see tri-, -ene)]
References in periodicals archive ?
Some asthma agents, such as montelukast, act as either leukotriene-related enzyme inhibitors (arachidonate 5-lipoxygenase) or leukotriene receptor antagonists.
The meta-analysis uncovered a significant association between omega-3 supplementation in reduction in thromboxane B2 in the blood of participants at high risk of cardiovascular disease and in leukotriene B4 in the neutrophils of unhealthy subjects.
Target: Rights to the leukotriene C4 synthase inhibitor programme (OX-CLI project)
Discriminant analysis revealed that these markers included three metabolites (dodecanal, 8-hydroxyguanosine, and leukotriene C4), three proteins (a1-antitrypsin, IgA-uromodulin complex, and galactose-deficient IgA1), and heparan sulfate (Box 2, Figure 1).
An oral version of the drug marketed as a generic and by Astra Zeneca as Accolate', is a first-in-class anti- leukotriene and treatment for asthma.
Leukotriene modifiers affect only one biochemical pathway--the lipoxygenase path and resulting leukotriene effects.
Omega-6 fatty acids are commonly thought to be pro-inflammatory, because linoleic acid (the major omega-3 fatty acid in the diet) is converted in part to arachidonic acid, which is a precursor for pro-inflammatory eicosanoids such as prostaglandin E2, leukotriene B4, and thromboxane A2.
16-20] Since inhaled or oral corticosteroids have not been shown to attenuate leukotriene production in vivo [21], therefore, a leukotriene receptor antagonist in combination with inhaled corticosteroid may confer additional benefits and could be the best combination.
10] Patients were excluded if they had significant co-morbidities, were receiving oral corticosteroids, LABAs, leukotriene antagonists or theophylline or had undergone an asthma exacerbation or lower respiratory tract infection within the four weeks prior to study entry.
The eosinophils will secret cationic protein when activated by leukotriene and IL-5.
Geha and his colleagues wondered whether the production of leukotriene B4 served to recruit T cells to the site of mechanical insult.
On the other hand, women were significantly more adherent than men were for leukotriene modifiers (0.