leukotriene


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leu·ko·tri·ene

 (lo͞o′kə-trī′ēn)
n.
Any of several lipid compounds that contain 20 carbon atoms, are related to prostaglandins, and mediate the inflammatory response.

[leuko(cyte) + triene, a compound containing three double bonds (tri- + -ene).]

leukotriene

(ˌluːkəʊˈtraɪiːn)
n
(Biochemistry) one of a class of products of metabolic conversion of arachidonic acid; the active constituents of slow-reacting substance, responsible for bronchial constriction, contraction of smooth muscle, and inflammatory processes
[C20: from leukocyte, in which they were discovered + triene from the conjugated triene unit that they contain]

leu•ko•tri•ene

or leu•co•tri•ene

(ˌlu kəˈtraɪ in)

n.
a lipid, C20H30O3, produced by white blood cells in an immune response to antigens, that contributes to allergic asthma and inflammatory reactions.
[1975–80; leuko- + triene (see tri-, -ene)]
References in periodicals archive ?
Bestatin (ubenimex) is a well-characterized, oral, small-molecule, dual-inhibitor of aminopeptidase and leukotriene A[sub.
An oral version of the drug marketed as a generic and by Astra Zeneca as Accolate', is a first-in-class anti- leukotriene and treatment for asthma.
Leukotriene modifiers affect only one biochemical pathway--the lipoxygenase path and resulting leukotriene effects.
Omega-6 fatty acids are commonly thought to be pro-inflammatory, because linoleic acid (the major omega-3 fatty acid in the diet) is converted in part to arachidonic acid, which is a precursor for pro-inflammatory eicosanoids such as prostaglandin E2, leukotriene B4, and thromboxane A2.
Geha and his colleagues wondered whether the production of leukotriene B4 served to recruit T cells to the site of mechanical insult.
The leukotriene inhibitors (montelukast and zafirlukast) and 5-lipoxygenase inhibitor (zileuton) improve airway function primarily by blocking the inflammatory effects of various leukotrienes (fig.
Leukotrienes have been implicated in the pathogenesis of eustachian tube dysfunction, (1-4) and a leukotriene receptor antagonist has been shown to be beneficial in preventing the development of middle ear fluid after an inflammatory challenge in the guinea pig model.
According to an FDA update from May, most of the reports of neuropsychiatric events were associated with montelukast, which is the most commonly prescribed drug that acts through the leukotriene pathway.
Of the leukotriene receptor antagonists, the most data are available on montelukast (Singulair).
The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene pathway such as asthma.
Inhibition of leukotriene synthesis occurred in a nonredox and noncompetitive manner.
5) Options for the management of these cases are to either increase the dose of ICS or to add in another controller agent, such as a long-acting beta-agonist (LABA), a leukotriene receptor antagonist (LTRA), or a theophylline.