Bestatin (ubenimex) is a well-characterized, oral, small-molecule, dual-inhibitor of aminopeptidase and leukotriene
An oral version of the drug marketed as a generic and by Astra Zeneca as Accolate', is a first-in-class anti- leukotriene
and treatment for asthma.
modifiers affect only one biochemical pathway--the lipoxygenase path and resulting leukotriene
Omega-6 fatty acids are commonly thought to be pro-inflammatory, because linoleic acid (the major omega-3 fatty acid in the diet) is converted in part to arachidonic acid, which is a precursor for pro-inflammatory eicosanoids such as prostaglandin E2, leukotriene
B4, and thromboxane A2.
Geha and his colleagues wondered whether the production of leukotriene
B4 served to recruit T cells to the site of mechanical insult.
inhibitors (montelukast and zafirlukast) and 5-lipoxygenase inhibitor (zileuton) improve airway function primarily by blocking the inflammatory effects of various leukotrienes
have been implicated in the pathogenesis of eustachian tube dysfunction, (1-4) and a leukotriene
receptor antagonist has been shown to be beneficial in preventing the development of middle ear fluid after an inflammatory challenge in the guinea pig model.
According to an FDA update from May, most of the reports of neuropsychiatric events were associated with montelukast, which is the most commonly prescribed drug that acts through the leukotriene
Of the leukotriene
receptor antagonists, the most data are available on montelukast (Singulair).
The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene
pathway such as asthma.
Inhibition of leukotriene
synthesis occurred in a nonredox and noncompetitive manner.
5) Options for the management of these cases are to either increase the dose of ICS or to add in another controller agent, such as a long-acting beta-agonist (LABA), a leukotriene
receptor antagonist (LTRA), or a theophylline.