Molecular characterization of lipoamide
dehydrogenase gene in Trypanosoma cruzi populations susceptible and resistant to benznidazole.
In that study 3 SNPs in creatine kinase, muscle (CKM), pyruvate dehydrogenase lipoamide
kinase isozyme 4 (PDK4) and cytochrome c oxidase, subunit 4, isoform 2 (COX4I2) genotype frequency distributions were significantly (P<0.
SIRT4 is also a lipoamidase that hydrolyzes the lipoamide
cofactors from the E2 component of the pyruvate dehydrogenase (PDH) complex, which reduces the activity of the complex .
The result was supported by Reed (1973), who thought that lipoamide
dehydrogenase was the flavoprotein component of the a-keto acid, and which was involved in Krebs cycle promoting energy metabolism.
Trypanothione reductase is a member of FAD-dependent NADPH oxidoreductase protein family and shares close structural similarities with GR, lipoamide
dehydrogenase and eukaryotic TrxRs (5).
Molecular basis of lipoamide
dehydrogenase deficiency in Ashkenazi Jews.