Reduces the expression of lipogenic
genes while increasing the expression of lipolytic genes.
2009) indicated that the supplementing of ALA in rats diet reduces the level of TG in blood and liver by repressing the gene expression of lipogenic
in liver, downregulating liver TG secretion and enhancing the clearance rate of TG.
Increased activity of the lipogenic
enzymes in adipose tissue may contribute to develop obesity.
Indeed, owing to insulin s lipogenic
actions, this treatment likely contributes to the ectopic lipid deposition (i.
The LBE treated cells showed a specific increase in expression of PPAR target gene expression, including fatty acid binding protein 4, fatty acid transport protein 4, CD36 molecule, pyruvate dehydrogenase kinase 4, liver X receptor alpha and lipogenic
One hypothesis to explain this distribution is that blood from the superior mesenteric vein containing lipogenic
alimentary factors that are preferentially distributed to the right lobe.
Our research, some of which we reported recently in the American Journal of Physiology, has shown increased expression of lipogenic
and inflammatory genes in maternal adipose tissue and in the placenta of obese women in the early first trimester, before any phenotypic change becomes apparent (Am.
Effect of dried bacillus subtilis culture on growth, body composition and hepatic lipogenic
enzyme activity in femal broiler chicks.
Several excellent reviews on the topic have recently been published (38, 39), with the balance of data supporting several critical metabolic functions including (a) anorexigenic action via central nervous system control of feeding behavior, (b) augmented glucose disposal in skeletal muscle via actions on several proteins in the insulin signaling pathway and by increased glucose transporter type 4 translocation, (c) prevention of visceral fat accumulation and decreased lipogenic
activity of lipoprotein lipase in adipose tissue, and (d) antiapoptotic effects on pancreatic [beta]-cells.
Polychlorinated biphenyls affect the activities of gluconeogenic and lipogenic
enzymes in rat liver: is there an interference with regulatory hormone actions?
Recent studies also have shown that liver-specific knockout of the gene encoding HDAC3 in mice leads to severe hepatic steatosis and increased expression of lipogenic
genes, although whether HDAC3 expression or function is altered by ethanol has yet to be elucidated (Sun et al.
Trigonellafoenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic