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antihistamine |
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antihistamine [ˌæntɪˈhɪstəˌmiːn -mɪn] n (Medicine / Pharmacology) any drug that neutralizes the effects of histamine, used esp in the treatment of allergies
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Because over-the-counter antihistamines are well known to cause fatigue, these medications were excluded from this analysis (this study was conducted before loratadine became available as an over-the-counter preparation, and therefore use of this drug was included in the analysis). Now, the Canadian team has done the same type of experiment with five common antihistamines: loratadine (Claritin), astemizole (Hismanal), hydroxyzine (Atarax), doxylamine (Unisom and Nyquil), and cetirizine (Reactine). CRx-197 is a selective cytokine modulator containing low concentrations of the allergy drug loratadine and the anti-depressant nortriptyline, neither of which is indicated for the treatment of dermatitis on its own but which have been shown to act synergistically in preclinical models of inflammation. |
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