Monacolin K has been identified to be structurally identical to the cholesterol-reducing drug lovastatin
As we continue to move our IBS-C program through two ongoing Phase 2 clinical trials, this research, along with SYN-010's novel modified-release formulation of the widely prescribed lovastatin
lactone, provides a strong body of support for SYN-010's efficacy in reducing methane levels in the gut.
However, the amounts of lovastatin
compounds in these three products were found to be as much as 88% higher to 33% lower than in 2011--suggesting they may now be more, or less, effective, respectively, than before.
7326/M13-2942), found that the average portion of days covered under prescribed statin therapy was 77% for patients started on generic lovastatin
, pravastatin, or simvastatin, and 71% for patients started on name brands of these medications (P < .
Coadministering a cytochrome P450 isoenzyme 3A4 (CYP3A4)inhibiting macrolide antibiotic, such as clarithromycin or erythromycin) (but not azithromycin) with atorvastatin (Lipitor[R]), simvastatin (Zocor[R]), or lovastatin
(Mevacor[R]), which are metabolized by CYP3 A4, is associated with a fourfold to 10-fold increase in statin concentrations.
A high mean daily dosage of lovastatin
was positively associated with the development of dementia, possibly because lovastatin
is a lipophilic statin while the anti-inflammatory cholesterol lowering effect of lovastatin
is not comparable to that of atorvastatin and simvastatin.
Clarithromycin and erythromycin inhibit the cytochrome P450 isoenzyme that metabolises atorvastatin, simvastatin, and lovastatin
Washington, December 28 ( ANI ): It has been found that adding lovastatin
, a widely used cholesterol-lowering drug, to traditional antimalarial treatment decreases neuroinflammation and protects against cognitive impairment in a mouse model of cerebral malaria.
Our aim was to investigate the possible and direct favorable effects of lovastatin
on lef t ventricular (LV) systolic, diastolic function and myocardial ischemia in patients with CAD.
The results indicated that coadministration of ezetimibe plus lovastatin
(pooled doses) was significantly more efficacious than lovastatin
alone (pooled doses) or ezetimibe alone in decreasing direct plasma levels of LDL cholesterol from baseline to endpoint.
In results which could be interesting news for the high numbers of Welsh men and women who suffer from heart disease and high cholesterol, the veggie diet fared almost as well as the standard anti-cholesterol drug lovastatin
is a naturally occurring ingredient of this preparation.