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Related to lyase: Ligases, Isomerases


Any of a class of enzymes that catalyze the cleavage of bonds without hydrolysis or oxidation, often resulting in a new double bond or ring structure, or that catalyze the addition of chemical groups to double bonds.

[Greek lūein, to loosen; see leu- in Indo-European roots + -ase.]


(Biochemistry) any enzyme that catalyses the separation of two parts of a molecule by the formation of a double bond between them
[C20: from Greek lusis a loosening + -ase]
References in periodicals archive ?
peroxidase and polyphenol oxidase and phenylalanine ammonia lyase were assayed at 4 different stages (0, 3, 6 and 9 days) to know about their role in defense mechanism of groundnut plants against stem rot disease.
The enzyme phenylalanine ammonia lyase (PAL) catalyzes the deamination of the amino acid phenylalanine at the entry of secondary phenylpropanoid/phenolic metabolism in plants [8].
When this 'switch' is turned on an enzyme called isocitrate lyase (ICL) is expressed, leading to activation of the T3SS.
TMS tests: Phenylketonuria, Isovaleric Acidemia, Type 1 Glutaric Aciduria, Medium Chain Acyl CoA Dehydrogenase (MCAD) deficiency, HMG CoA lyase deficiency.
Increased citrulline indicates a deficiency in either argininosuccinate synthase or argininosuccinate lyase (1).
CONCLUSIONS: Licorice can reduce serum testosterone probably due to the block of 17-hydroxysteroid dehydrogenase and 17-20 lyase.
In this invention, several bathochromic phytochromes were generated by site-directed mutagenesis in the region of bilin lyase domain in plant PHYA, and their ability to suppress the shade avoidance reactions were examined by transforming the bathochromic phytochromes into PHYA deficient Arabidopsis thaliana (ecotype col-0).
Specific topics are thermodynamics of the dissociation of weak acids, apparent equilibrium constants, biochemical reactions at specific temperatures and pHs, the use of matrices, the binding of ligands by proteins, calorimetry, and oxidoreductase, transferase, hydrolase, and lyase reactions.
tuberculosis that lack the gene for this enzyme, known as isocitrate lyase, had concentrations of the disease-causing bacteria in their lungs similar to those in mice infected with normal M.
The enzyme complex includes pectin esterase, polygalacturonase, pectin lyase, and arabanase.
The US Food and Drug Administration has accepted for Priority Review the Biologics License Application for pegvaliase, a PEGylated recombinant phenylalanine ammonia lyase enzyme product, to reduce blood phenylalanine levels in adult patients with phenylketonuria who have uncontrolled blood Phe levels on existing management, US-based biotechnology company BioMarin Pharmaceutical Inc.
United States-based BioMarin Pharmaceutical has submitted a Biologics License Application to the United States Food and Drug Administration (FDA) for Pegvaliase, a PEGylated recombinant phenylalanine ammonia lyase enzyme product, it was reported yesterday.