Through the application of its mRNA
Technology Platform, PhaseRx has demonstrated highly effective and selective expression to liver with multiple mRNAs
, with no expression observed in other tissues.
As part of the agreement, BioNTech will combine the use of its proprietary mRNA
technology platform with its extensive capabilities in developing immune-stimulating pharmaceuticals, utilise its mRNA
formulation technology that enables targeted mRNA
delivery in vivo to generate novel cancer immunotherapies as well as supply part of the mRNA
material needed for development activities from its in-house GMP manufacturing unit.
The vaccines work of Valera builds on a body of preclinical research at Moderna showing the ability of modified mRNA
to express viral antigens in vivo and to induce robust immune responses.
Previously we introduced a unique system of leukocyte mRNA
analysis from whole blood, in which leukocytes were trapped on a 96-well filter plate and leukocyte lysate was transferred to a 96-well oligo(dT)-immobilized microplate for direct poly[(A).
Extracting enough mRNA
to conduct the studies was a difficult task because metabolic rates of microorganisms in the deep biosphere are very low and mRNA
is about only 4 to 10 percent of the total RNA they make, Orsi said.
Taking into consideration the nucleic acid types, size and function of messenger RNA, Oz Biosciences has developed new specific reagents allowing mRNA
transfection with high efficiency.
The main objectives of this study were to develop a qualitative reverse transcription PCR (RT-PCR) detecting spliced mRNA
from HBoV1 and to clarify whether HBoV1 mRNA
detection may correlate better than DNA detection with RTIs in children.
We found that quantification of cells overexpressing E6, E7 mRNA
in cervical cytology samples exhibited higher sensitivity and specificity than Papanicolaou (Pap) staining for high-grade lesions on biopsy in women younger than 30 years.
moves out of the nucleus of the cell to a free ribosome in the cytoplasm to begin the process of protein synthesis.
Working on the idea that the signature of a cell is defined by molecules called messenger RNAs (mRNAs
), which contain the chemical blueprint for how to make a protein, the investigators changed two different cell types, an astrocyte (a star-shaped brain cell) and a fibroblast (a skin cell), into a heart cell, using mRNAs
acts as a surrogate marker for circulating thyroid cancer cells, and in initial studies distinguished benign from malignant thyroid diseases.
In the present study, porcine GLUT4 cDNA was cloned by RACE method, and the tissue distribution and developmental expression pattern of GLUT4 mRNA
in Landrace were conducted by Real-time RT-PCR analysis.