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macrocyte

   Also found in: Medical, Encyclopedia, Wikipedia 0.03 sec.
mac·ro·cyte  (mkr-st)
n.
An abnormally large red blood cell, especially one associated with pernicious anemia.

macro·cytic (-stk) adj.

macrocyte [ˈmækrəʊˌsaɪt]
n
(Medicine / Pathology) Pathol an abnormally large red blood cell, over 10 μm in diameter
macrocytic  [ˌmækrəʊˈsɪtɪk] adj
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.macrocyte - abnormally large red blood cell (associated with pernicious anemia)macrocyte - abnormally large red blood cell (associated with pernicious anemia)
erythrocyte, RBC, red blood cell - a mature blood cell that contains hemoglobin to carry oxygen to the bodily tissues; a biconcave disc that has no nucleus


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Laboratory data usually show severe and progressive hypochromic anemia, leukopenia with a predominance of lymphocytes and macrocytes, thrombocytopenia, hypoalbuminemia with polyclonal hypergamaglobulinemia and, at times, even an increase in liver function tests.
Diagnostic Features: Pancytopenia, oval macrocytes,and hypersegmented neutrophils; megaloblastic hyperplasia; achlorhydria; anti-intrinsic factor antibodies; absent position and vibration sensations; impaired vitamin B12 absorption corrected by intrinsic factor (abnormal Schilling test) =>Folate deficiency +Mechnisms: Delayed DNA replication +Diagnostic Features: Pancytopenia, oval mcrocytes, and hypersegmented neutrophils; megaloblastic hyperplasia.
 
 
 
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